Despite a slow start, Roberto Mancini’s side went in at the interval two goals up courtesy of strikes from Federico Bernardeschi – the Juventus man’s sixth international goal – and Gian Marco Ferrari.
Matteo Politano and Matteo Pessina added braces after the break, while Andrea Belotti was also on target as Italy brushed aside their neighbours with the minimum of fuss.
The result marked the Azzurri’s seventh consecutive win without conceding a goal.
Italy struggled in the early stages against their less illustrious opponents, with only Gianluca Mancini and Bernardeschi registering efforts on target inside the opening half hour.
They went ahead after 31 minutes, however, when Bernardeschi’s low strike from 20 yards proved too powerful for San Marino goalkeeper Elia Benedettini.
Sassuolo defender Ferrari, who scored on his only other appearance for Italy against San Marino in 2017, doubled their advantage three minutes later, volleying home after Benedettini had failed to clear a corner.
Half-time substitute Politano wasted little time making his mark on the game, sliding in his third international goal in the 49th minute after a mix-up in the San Marino defence.
Belotti added a fourth after 67 minutes, the Torino striker latching onto Bernardeschi’s pass and firing past Benedettini from eight yards.
Pessina stroked home a fifth in the 75th minute after Gaetano Castrovilli had struck the post from outside the penalty area, while Politano added his second two minutes later with a fine volley from 12 yards.
Atalanta midfielder Pessina then rounded off the scoring four minutes from full-time with a poked finish from a tight angle.
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