THCV is one of the many cannabinoids in the cannabis plant; its quantity varies and is particularly high in some strains from Africa or Asia, according to UNODC. This cannabinoid isn’t psychoactive, meaning it doesn’t produce the same intoxicating effects as THC. However, research has found that tetrahydrocannabivarin does cause some other effects related to appetite and energy levels.
The amount of THCV present in a typical cannabis flower varies and depends largely on the strain. However, the chemical tends to be present in far lower quantities than its better-known cannabinoid counterparts. The NIH shows that THCV is, chemically speaking, very similar to THC. It also works on the same cannabinoid 1 and 2 (CB1 and CB2) receptors in the brain. These receptors are responsible for regulating other neurotransmitters, as well as some physiological functions like appetite.
In the case of THC, it causes more activity at the CB1 receptor, increasing euphoric feelings and the drive to eat, as explained in a study published in the British Journal of Pharmacology. THCV, on the other hand, reduces activity at the CB1 receptor. This means that the cannabinoid can potentially reduce the effects of THC, including negative ones, in addition to suppressing appetite.
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